I conducted a genome-wide CRISPR knockout screen in ovarian cancer cells to identify genes regulating cell stiffening and softening. Using a high-throughput microfluidic device I optimized for mechanical phenotyping, I screened tens of millions of cells with single gene knockouts and uncovered key genes (such as CCDC88A, GSK3B, and PIK3R4) linked to mechanical state and poor prognosis in ovarian cancer. This project was supported by an NIH F31 Fellowship, for which I served as principal investigator.